Buffalo Center for 
      Biomedical Computing
   
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     The Center represents an integration of the computational and biomedical research efforts of institutions and scientists from the University at Buffalo-SUNY (UB) and the Roswell Park Cancer Institute (RPCI), an NCI cancer center. The members of this team have expertise in computer science, pharmacology, molecular biology, pharmacokinectics and pharmacodynamics, neurology, cancer, cardiovascular disease and epidemiology. Indeed, members of this group have been working together on problems requiring the development of new computational approaches and their efforts have begun to yield fruit resulting in joint publications. These scientists are drawn from the departments of Computer Science and Engineering (UB), Pharmaceutical Sciences (UB), Mathematics (UB), Biology (UB), Molecular and Cellular Biology (RPCI) and Social and Preventive Medicine (UB).
   
  University at Buffalo logo The State University of New York at Buffalo (UB) is New York State's major public university. It is the largest public graduate and research center in New York and New England with 80,000 graduates living and working throughout the nation. Founded in 1846, UB is putting the finishing touches on one of the northeast's most modern educational facilities. An award-winning faculty of 5,800 full-time and affiliated instructors provide educational opportunities for 26,000 students each year. Almost 9,000 of these are enrolled in graduate and post-baccalaureate professional programs. More than a dozen investigative centers and institutes are part of a research effort which exceeded $250 million in expenditures last year.
   
  Roswell Park logo The Roswell Park Cancer Institute (RPCI), founded in 1898, is the only NCI-designated Comprehensive Cancer Center in the upstate New York area. The Institute's mission is to provide total care to the cancer patient, to conduct research into the causes, treatment and prevention of cancer, and to educate the public and the next generation of those who study and treat cancer. RPCI has highly specialized interests and expertise in using genomics in cancer research.
 

The Buffalo Center of Excellence in Bioinformatics (CoE)--   New York State has committed $62 million and private industry has committed more than $150 million toward a 130,000 sq. ft. facility in Buffalo to house the BCEB headed by Dr. Jeffrey Skolnick. At the BCEB, the merger of high-performance computing and high-end visualization, genomics, proteomics, and bioimaging is a unique and powerful combination of technologies and research expertise, poising the center to make critical scientific contributions in the biomedical research. The Center will be able to leverage the activities of several currently existing centers in Buffalo involved in bioinformatics research including the BCEB. We plan to become a key component of the BCEB by providing advanced tools for biomedical scientists.

The UB Center for Computational Research (CCR)--   The UB CCR is one of the leading academic high-performance computing and high-end visualization centers. The CCR's extensive computing facilities include a 128 processor SGI Origin2000 supercomputer, a 42 processor IBM RS/6000 SP supercomputer, and a Linux/Beowulf cluster of 64 Sun Ultra5 workstations. The computer visualization laboratory features a PyramidSystems ImmersaDesk, an SGI Onyx2 Infinite Reality2 graphics computer, and several high-end graphics workstations. UB is also continuing to invest its computing infrastructure. In collaboration with Dell Computer Corporation, two new supercomputing clusters have been installed this year valued at over $13 million. A 5.8 teraflops (TF) Dell Pentium Cluster with 3830 Pentium III and 206 Pentium 4 processors has been installed for use by the BCEB. A second 304 node Dell Cluster has been installed in the CCR. This 2.9TF system is fully connected with a Myrinet backbone and will serve the UB community. These investments have made UB the sixth most powerful supercomputing center in the world and the top academic computational center according to gapcon.com.

The Department of Computer Science and Engineering (CSE)--   The faculty in CSE reflects the diversity of this broad vision of computation, including nationally and internationally recognized experts in the areas of: computational science and engineering; computer networks; intelligent systems; multimedia and databases; software engineering and languages; theory and algorithms; and VLSI and computer architecture. Members of the faculty conduct research with other UB faculty in a variety of areas, including Biophysics; Cognitive Science; Crystallography; Pharmaceutical Sciences, Structural Biology, Geographical Information Systems and Industrial Engineering. This organization reflects UB's commitment to a modern integrated environment for research and education in computing, suited to the emerging shape of information science and technology in the new millennium. These new expressions of computation are best studied in a flexible, integrated environment in which computer science and computer engineering are parts of a whole, and in which partnerships with other disciplines, including biomedicine are routine.

The Department of Social and Preventive Medicine (SPM)--   The SPM in the School of Public Health and Health Professions, has been a leader at UB in attracting extramural funds to support its research mission. SPM main research activities focus on Epidemiology and the department operates a fully equipped clinical research facility (The Center for Preventive Medicine) where study participants are interviewed and examined to collect detailed clinical histories and status and laboratory facilities where clinical specimens are prepared and stored for future genotyping. A state-of-the-art tissue specimen bank (containing serum, heparin and citrate plasma, packed red blood cell, DNA) currently has samples from more that 6000 subjects (recruited as part of a series of population-based case-control studies on coronary heart disease and cancer being conducted since 1995) linked to detailed clinical personal and family histories, physical measurements (e.g. height, weight, abdominal height, waist and hip circumferences, blood pressure, lung function, serum lipids (total and HDL cholesterol, triglycerides), glucose, liver enzymes, antioxidant vitamins, markers of oxidative stress, and detailed information about life style habits (e.g. diet physical activity, smoking, etc) occupational and residential histories. The Department has maintained over the years a distinguished record of extramurally funded research in epidemiological investigations.

The Department of Pharmaceutical Sciences (PHC)--    The PHC in the School of Pharmacy and Pharmaceutical Sciences has long held an outstanding international reputation in the areas of pharmacokinetics and pharmacodynamics and the School is regarded as one of the top institutions in the U.S. Pharmacodynamics serves as an analytical, theoretical and interpretive interface between the experimental aspects of biology and pharmacology and the quantitative areas of bioanalysis, mathematics, computer science and statistics. The department is expanding into the area of pharmacogenomics and bioinformatics in its teaching, research and training efforts and is well equipped to use pharmacodynamics as a means of characterizing and understanding drug effects on genomic processes.

Center of Excellence in Information Systems Assurance Research and Education (CEISARE)--    Higher education in Information Assurance (IA) and a greater number of professionals with IA expertise are essential to meet the challenges and threats to the National Information Infrastructure. The goals of this Center of Academic Excellence in Information Systems Assurance, Research and Education (CEISARE@Buffalo) are graduate education and coordinated research in computer security and information assurance by faculty members from several schools and departments at the University at Buffalo. State University of New York at Buffalo has been re-designated as a National Center of Academic Excellence in Information Assurance Education for the Academic Years 2008-2013. In 2009, the University has been designated as a CAE-R (Center of Excellence in Research) as well for the Academic Years 2009-2014. The Center has also been certified to have met the Information Systems Security Professionals, NSTISSI No. 4011 and Systems Administrators, CNSSI No. 4013 for 2008-2013. In 2010, CEISARE's research and educational activities have been expanded to Biomedical Data Security.