The Center has organized a multi-disciplinary program team to address fundamental research issues in biocomputing while contributing to mid-to long-term research, development, and experimental deployment challenges of analyzing genomic data for diseases and treatment effects. The overall theme of the center is "Advanced Data Mining Algorithms for Applications in Genomics." We will provide the expertise and infrastructure that will merge the research activities of computational and biomedical scientists. The focus of the proposed research is the study of common diseases, such as cancer, multiple sclerosis and coronary artery disease in which the underlying causes are multi-factorial. In this new paradigm, we will use advanced computational techniques and approaches to convert raw genomic data into knowledge that will advance the understanding of these common diseases and potentially identify new modalities of treatment.